Use of pretreatment prostate-specific antigen doubling time to predict outcome after radical prostatectomy
نویسندگان
چکیده
منابع مشابه
Time to prostate specific antigen recurrence after radical prostatectomy and risk of prostate cancer specific mortality.
PURPOSE In patients treated with radical prostatectomy who have biochemical recurrence we have previously reported that time from surgery to biochemical recurrence and postoperative prostate specific antigen doubling time are significantly related to the risk of prostate cancer death. We performed a more thorough examination of the association of time from surgery to biochemical recurrence and ...
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The disappearance pattern of prostate-specific antigen from serum after a standard radical prostatectomy was studied in eight patients with cancer confined to the prostate. The results were used to plot an elimination curve and calculate the best fit. A biphasic pattern was found with an average biological half-life of 1.63 hours in the alpha-phase, and 4.63 days in the beta-phase. Based on the...
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Introduction Serum prostate-specific antigen (PSA) is of paramount importance as a diagnostic tool for the detection, staging, and monitoring of patients with prostate cancer. Because PSA is organ but not disease specific, it has certain limitations as a screening test for prostate cancer. After radical prostatectomy (RP), however, PSA is an excellent tumor marker with a high sensitivity and sp...
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Background: Prostate cancer has been reported as a worldwide important kind of cancer and the second most common cause of cancer-related mortality among men. Prostate-specific antigen (PSA) serum level is one of the most important markers of prostate cancer diagnosis. While PSA level helps predict the risk of prostate cancer development, researchers still looking for ways to increase the accura...
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Despite the prostate-specific antigen (PSA) serum level commonly uses as tumor marker in diagnosis of prostate cancer, it seems that PSA doubling time (PSADT) could be more useful indicator of tumor behavior and of prognosis for patients. The results of hormone and radiation therapy were evaluated for 912 prostate cancer having at least 2 PSA tests before the treatment was started. Clustering p...
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ژورنال
عنوان ژورنال: Prostate Cancer and Prostatic Diseases
سال: 2000
ISSN: 1365-7852,1476-5608
DOI: 10.1038/sj.pcan.4500424